High Na+ Environments Impair Phagocyte Oxidase-Dependent Antibacterial Activity of Neutrophils
Infection and inflammation can augment local Na+ abundance.These increases in local Na+ levels boost proinflammatory and antimicrobial macrophage activity and can favor polarization of T cells towards a proinflammatory Th17 phenotype.Although neutrophils play an important role in fighting intruding invaders, the impact of increased Na+ on the antim